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Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14
Abstract:
We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses.
Insights
Oseltamivir-resistant influenza A(H1N1)pdm09 viruses were found in the US during 2013-14. Local surveillance is crucial for monitoring neuraminidase inhibitor susceptibility in circulating flu strains.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Influenza A(H1N1)pdm09 is a significant human pathogen.
- Neuraminidase inhibitors like oseltamivir are key antiviral treatments.
- Emergence of drug resistance can impact treatment efficacy.
Purpose of the Study:
- To characterize oseltamivir-resistant influenza A(H1N1)pdm09 viruses.
- To describe patients infected with these resistant strains in the US.
- To highlight the importance of ongoing surveillance for antiviral resistance.
Main Methods:
- Analysis of influenza virus samples collected in the US during the 2013-14 season.
- Genomic sequencing to identify specific mutations conferring resistance, such as H275Y.
- Clinical data collection from infected patients.
Main Results:
- Fifty-nine (1.2%) of 4,968 analyzed influenza A(H1N1)pdm09 viruses exhibited the H275Y substitution.
- This substitution confers resistance to oseltamivir.
- The findings indicate a detectable prevalence of resistance in the US during the study period.
Conclusions:
- Oseltamivir resistance in influenza A(H1N1)pdm09 is present in the United States.
- The H275Y mutation is a key marker for oseltamivir resistance.
- Continuous local surveillance of neuraminidase inhibitor susceptibility is essential for effective influenza management.
