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Anticancer agents from diverse natural sources.

Jabeena Khazir, Darren L Riley, Lynne A Pilcher

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    Natural products from plants, microbes, and marine life are crucial for discovering new anticancer drugs. These natural compounds serve as templates for developing effective cancer treatments currently in use and clinical trials.

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    Area of Science:

    • Pharmacology and Natural Product Chemistry
    • Oncology Drug Discovery

    Background:

    • Natural products have historically served as a foundation for treating human diseases.
    • Compounds derived from nature, including plants, microbes, and marine organisms, are vital sources for novel therapeutics.
    • Many existing and investigational anticancer agents originate from natural sources or are synthetic modifications thereof.

    Purpose of the Study:

    • To review the discovery and development of anticancer agents derived from diverse natural sources.
    • To highlight the significant role of natural products in identifying and creating new cancer treatments.

    Main Methods:

    • Literature review of scientific publications on natural products and anticancer drug discovery.
    • Analysis of the origins and development pathways of naturally derived anticancer agents.
    • Examination of compounds currently in clinical trials and on the market.

    Main Results:

    • Natural molecules from various sources have been instrumental in developing anticancer drugs.
    • Numerous successful anticancer drugs are either naturally derived or synthetic analogues.
    • A substantial number of natural product-based anticancer agents are undergoing clinical evaluation.

    Conclusions:

    • Natural products remain an invaluable resource for the discovery of novel anticancer agents.
    • The continued exploration of natural sources is essential for advancing cancer therapy.
    • Natural products provide unique chemical scaffolds that inspire the development of new anticancer drugs.