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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

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A photoCORM nanocarrier for CO release using NIR light.

Agustin E Pierri¹, Po-Ju Huang, John V Garcia

¹Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. ford@chem.ucsb.edu.

Chemical Communications (Cambridge, England)

|December 24, 2014

Summary

Researchers developed a water-soluble nanocarrier for a photo-activated carbon monoxide (CO) releasing molecule (photoCORM). This system uses near-infrared light for controlled CO delivery to biological targets.

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Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Carbon monoxide (CO) has therapeutic potential but requires precise delivery.
Existing CO delivery methods face challenges in solubility and targeted activation.
Photoactivated CO-releasing molecules (photoCORMs) offer temporal control over CO release.

Purpose of the Study:

To develop a novel water-soluble nanocarrier system for targeted CO delivery.
To encapsulate a photoCORM within a nanostructure for enhanced stability and biocompatibility.
To enable CO release upon near-infrared (NIR) light stimulation for biological applications.

Main Methods:

Synthesis of an upconversion nanoparticle core.
Encapsulation of the photoCORM trans-Mn(bpy)(PPh3)2(CO)2 within an amphiphilic polymer.
Characterization of the nanocarrier's water solubility and hydrophobic interior.
Demonstration of NIR-triggered CO release.

Main Results:

A stable, water-soluble nanocarrier was successfully fabricated.
The nanocarrier effectively encapsulated the hydrophobic photoCORM.
Near-infrared (NIR) light was confirmed to trigger CO release from the nanocarrier.
The system demonstrated potential for targeted CO delivery to biological systems.

Conclusions:

The developed nanocarrier provides a unique and effective strategy for water-soluble, photo-activated CO delivery.
This platform holds promise for advancing therapeutic applications of CO.
Further research can explore in vivo efficacy and specific biological targeting.