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Updated: Apr 19, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Experimental and computational study of the catalytic asymmetric 4π-electrocyclization of N-heterocycles
Sadiya Raja1, Masaki Nakajima, Magnus Rueping
1Institut of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074 Aachen (Germany).
Abstract:
The first asymmetric metal-catalyzed Nazarov cyclization of N-heterocycles has been developed. The use of a chiral catalyst allows the enantioselective electrocyclization of N-heterocycles under mild conditions and the corresponding products are obtained in good yields with excellent enantio- and diastereoselectivity. The reaction mechanism and the absolute configuration of the obtained products are explained by means of computational studies.
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