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N-cadherin antagonists as oncology therapeutics

Orest W Blaschuk1

  • 1Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada H3A 1A1 orest.blaschuk@mcgill.ca.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|December 24, 2014
PubMed

Insights

N-cadherin, a cell adhesion molecule, is a promising oncology target. Disrupting its interactions with antagonists offers a novel anti-cancer therapy strategy by inhibiting tumor cell proliferation and metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • N-cadherin is a cell adhesion molecule (CAM) crucial for blood vessel integrity.
  • Aberrant N-cadherin expression is observed in various poorly differentiated tumors.
  • N-cadherin influences cancer cell proliferation, survival, invasiveness, and metastasis.

Purpose of the Study:

  • To review the discovery and function of N-cadherin.
  • To elucidate the role of N-cadherin in angiogenesis and cancer progression.
  • To discuss N-cadherin antagonists as a novel anti-cancer therapeutic strategy.

Main Methods:

  • Literature review of N-cadherin's role in cell adhesion and cancer.
  • Analysis of N-cadherin's involvement in blood vessel formation and maintenance.
  • Examination of various N-cadherin antagonists and their therapeutic potential.

Main Results:

  • N-cadherin mediates cell adhesion and is vital for vascular integrity.
  • Its dysregulation is linked to tumor progression and metastasis.
  • Peptide and small molecule antagonists targeting N-cadherin interactions show therapeutic promise.

Conclusions:

  • N-cadherin is a significant target in oncology due to its role in cancer progression.
  • Targeting N-cadherin interactions represents a novel and promising anti-cancer therapeutic approach.
  • Further development of N-cadherin antagonists could lead to effective cancer treatments.
Keywords:
ADH-1N-cadherin antagonistsangiogenesiscancerendothelial cells

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