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Updated: Apr 19, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Vertical bone augmentation induced by ultrathin hydroxyapatite sputtered coated mini titanium implants in a rabbit
Xin Wang1, Osama Zakaria1,2, Marwa Madi3
1Department of Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Background:
The purpose of this study was to evaluate the vertical new bone formation induced by sputtered HA-coated titanium implants (HA-coated) compared with sandblasted acid-etched titanium implants (noncoated) in a rabbit calvarial model.
Materials And Method:
Twenty HA-coated and 20 noncoated titanium implants were divided equally into four groups as HA-coated implant (HA); noncoated implant (NC); HA-coated implant with membrane (HA/M); noncoated implant with membrane (NC/M). All implants were placed 5 mm above the original bone (OB). Collagen membranes were placed over the implants in HA/M and NC/M groups. The animals were sacrificed at 4 weeks (n = 5) and 8 weeks (n = 5). Vertical bone height above OB (VBH, mm) and augmented bone area (ABA, mm(2) ) were analyzed histologically and radiographically.
Results:
At 4 weeks, VBH reached significantly higher level in HA/M group compared with other three groups (p < 0.05). At 8 weeks, significant difference was detected between HA/M and NC groups (p < 0.05). At 4 and 8 weeks, ABA in HA/M group was significantly larger compared with other three groups (p < 0.05).
Conclusion:
The present results indicated that sputtered HA-coated titanium implant together with collagen membrane could be a novel and effective approach for vertical bone augmentation.
