Turner syndrome--issues to consider for transition to adulthood
Laura Lucaccioni1, Sze Choong Wong1, Arlene Smyth2
1Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Dalnair Street, Glasgow, UK.
British Medical Bulletin
|December 24, 2014
Summary
Turner syndrome (TS) requires lifelong health management, including hormone replacement and monitoring for autoimmune conditions and cardiovascular risks. Transitioning care and further research are crucial for optimizing health outcomes in individuals with TS.
Area of Science:
- Endocrinology
- Genetics
- Adolescent Medicine
Background:
- Turner syndrome (TS) presents a wide range of health issues throughout life.
- Adolescents with TS require special attention during their transition to adulthood.
Purpose of the Study:
- To highlight the ongoing health challenges in Turner syndrome.
- To identify areas needing further research and improved healthcare models.
Main Methods:
- Review of existing literature on Turner syndrome management.
- Identification of key clinical issues and research gaps.
Main Results:
- Most girls with TS need estrogen replacement for feminization, uterine development, and bone health.
- Increased lifetime risks include autoimmune diseases (hypothyroidism, celiac disease), hearing loss, and aortic dilatation.
- Unanswered questions persist regarding optimal hormone therapy, cardiovascular assessment, and pregnancy management.
Conclusions:
- A systematic and holistic healthcare approach is necessary for TS.
- Further research is essential for cardiovascular risk, pregnancy management, and hormone replacement therapy in TS.
- Optimizing care models and transition to adult services is critical.
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