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Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis

Melissa Sorosina1, Federica Esposito2, Clara Guaschino2

  • 1Laboratory of Genetics of Neurological complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 24, 2014
PubMed

Insights

Genetic risk score influences multiple sclerosis (MS) onset differently. Higher scores predict earlier onset in inflammatory MS but later onset in progressive MS, impacting disease phases.

Area of Science:

  • Genetics
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) has complex genetic underpinnings.
  • Understanding genetic contributions to MS disease course is crucial.

Purpose of the Study:

  • To investigate the association between genetic risk score and age at onset in different MS subtypes.
  • To determine if genetic factors influence the inflammatory versus progressive phases of MS.

Main Methods:

  • Correlated a weighted genetic risk score (107 variants) with age at onset.
  • Analyzed data from Italian patients with bout-onset MS (BOMS) and progressive-onset MS (PrMS).

Main Results:

  • A higher genetic risk score correlated with earlier onset in BOMS (p=5 × 10(-3)).
  • A higher genetic risk score showed a trend towards later onset in PrMS (p=0.15).
  • The difference in regression between disease courses was statistically significant (p=1.4 × 10(-2)).

Conclusions:

  • Established MS genetic risk variants appear to influence the onset of the inflammatory phase.
  • These variants may not impact, or could even delay, the onset of the progressive phase of MS.
Keywords:
Primary-progressiveage of onsetgenetic riskmultiple sclerosisrelapsing–remittingweighted genetic risk score

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