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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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Drug Product Stability01:16

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The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
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Drug stability analysis by Raman spectroscopy.

Chetan Shende1, Wayne Smith2, Carl Brouillette3

  • 1Real-Time Analyzers, Inc., Middletown, CT 06457, USA. chetan@rta.biz.

Pharmaceutics
|December 24, 2014
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Summary
This summary is machine-generated.

Raman spectroscopy can detect drug degradation in spaceflight medications. This method quickly quantifies drug mixtures and their byproducts, ensuring astronaut safety by verifying pharmaceutical potency.

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Area of Science:

  • Space medicine
  • Analytical chemistry
  • Pharmaceutical science

Background:

  • Spaceflight poses unique challenges to pharmaceutical drug stability.
  • In-flight medications may degrade faster in microgravity, potentially forming toxic byproducts.
  • Ensuring the potency and safety of astronaut medications is critical.

Purpose of the Study:

  • To investigate Raman spectroscopy for quantifying drug-degradant mixtures.
  • To assess the feasibility of using Raman spectroscopy for in-flight drug analysis.

Main Methods:

  • Utilized Raman spectroscopy to analyze mixtures of acetaminophen, azithromycin, epinephrine, and lidocaine with their degradation products.
  • Employed classical least squares (CLS) multivariate analysis to model and quantify spectral contributions.
  • Determined drug and degradant concentrations by combining pure drug and degradant spectra.

Main Results:

  • Successfully quantified mixtures of four drugs and their primary degradation products.
  • Achieved concentration determination in approximately 10 minutes.
  • Established a limit of detection of approximately 4% for drug degradants.

Conclusions:

  • Raman spectroscopy is a viable method for non-destructively assessing drug potency in spaceflight.
  • A Raman analyzer could provide real-time drug quality control, enhancing crew safety.
  • This technique offers a rapid and effective solution for monitoring pharmaceutical stability in space environments.