[Uremic neuropathy]

Two autopsy cases of uremic neuropathy were reported. The chief clinical features were progressive peripheral sensory impairment, especially of the deep sensation, and the distal weakness of the four extremities. Histopathological findings revealed not only marked segmental demyelination and axonal degeneration of the peripheral nerves, but also severe damage of the skeletal muscles, including the necrosis of the myofibers, streaming of the Z-band, aggregation of glycogen, and the presence of membranous bodies under the electron microscope. It indicated that both the peripheral nerves and the skeletal muscles were involved in some metabolic diseases.