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Clinical aspects of vitamin D-binding protein gene polymorphisms in hemodialysis patients
Insights
Vitamin D-binding protein gene (GC) polymorphisms are similarly distributed in hemodialysis patients and healthy individuals. However, GC variants are linked to 25-hydroxy vitamin D levels and sex-specific mineral disorders in hemodialysis patients.
Area of Science:
- Genetics and Molecular Biology
- Nephrology
- Endocrinology
Background:
- Limited data exist on the association between vitamin D-binding protein gene (GC) polymorphisms and chronic kidney disease (CKD) manifestations.
- Understanding these associations is crucial for managing CKD complications.
Purpose of the Study:
- To investigate the frequency distribution of GC polymorphisms in hemodialysis (HD) patients and healthy controls.
- To examine the relationship between GC variants and coronary artery disease (CAD), myocardial infarction (MI), and secondary hyperparathyroidism indices in HD patients.
Main Methods:
- Genotyping of GC polymorphisms (rs2298849, rs7041, rs1155563) in 1056 HD patients and 313 healthy controls.
- Analysis of clinical data (CAD, MI prevalence) and laboratory markers (serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 25-hydroxy vitamin D [25(OH)D]).
Main Results:
- No significant differences in GC polymorphism frequency distribution were observed between HD patients and controls.
- Lower plasma 25(OH)D levels were associated with the rs7041 TT genotype compared to the GG genotype (P=0.02).
- Women with the rs7041 TT genotype exhibited higher serum phosphorus levels than those with the GG genotype (P=0.007).
Conclusions:
- HD patients do not differ from healthy subjects in the distribution of the studied GC polymorphisms.
- GC polymorphism is associated with plasma 25(OH)D levels in HD patients.
- Sex-specific factors may influence the association between GC variants and mineral metabolism disorders in CKD.
Introduction:
There are scarce data on the associations between vitamin D-binding protein gene (GC) polymorphisms and manifestations of chronic kidney disease.
Objectives:
We evaluated the frequency distribution of GC polymorphic variants in hemodialysis (HD) patients and healthy subjects as well as the differences in the prevalence of coronary artery disease (CAD) and myocardial infarction (MI) and selected clinical and laboratory indices of secondary hyperparathyroidism in HD patients (women and men) with different GC polymorphic variants.
Patients And Methods:
HD patients (n = 1056; 625 men) and healthy controls (n = 313; 150 men) were enrolled into the study. The tested GC polymorphisms included rs2298849, rs7041, and rs1155563. We analyzed clinical data (prevalence of CAD and MI; treatment with parathyroidectomy or cinacalcet) and laboratory results (serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25-hydroxy vitamin D [25(OH)D] in relation to the gene polymorphisms.
Results:
There were no differences between the study groups themselves and between the study groups and controls in terms of the frequency distribution of GC polymorphisms (Ptrend <0.05). Lower plasma 25(OH)D levels were shown in subjects with the rs7041 TT genotype compared with those with the GG genotype (12.7, 5.7-20.9 ng/ml vs. 15.9, 8.0-50.0 ng/ml, P = 0.02). Women with the rs7041 TT genotype compared with those with the GG genotype showed higher serum phosphorus levels (5.58, 3.40-8.97 mg/dl vs. 5.03, 1.75-9.33 mg/dl, P = 0.007).
Conclusions:
HD patients do not differ in the distribution of GC polymorphisms rs2298849, rs7041, and rs1155563 from healthy subjects. In HD patients, the GC polymorphism is associated with plasma 25(OH)D levels. Sex-related factors may be important in the expression of associations between GC polymorphic variants and mineral disorders.
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