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Updated: Apr 19, 2026
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Serum endocan concentration in women with pre-eclampsia
Mehmet Aytac Yuksel1, Abdullah Tuten, Mahmut Oncul
1Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Kocamustafapasa, Istanbul, Turkey, maytacyuksel@gmail.com.
Purpose:
To investigate serum endocan levels in pregnant subjects with and without pre-eclampsia.
Methods:
This cross-sectional study was conducted on 49 pregnant women with pre-eclampsia and 32 healthy pregnant women matched for gestational age. Maternal levels of serum endocan were measured with the use of an enzyme-linked immunosorbent assay kit.
Results:
Mean endocan levels were not significantly different among groups (10.7 ± 4.5 vs. 10.3 ± 3.2 ng/mL, p 0.763). Mean uterine artery PI and RI were higher in the pre-eclampsia group (p < 0.001, p < 0.001). Mean endocan levels were negatively correlated with BMI at the time of blood sampling (r = -0.247, p = 0.044). There was no correlations between mean endocan levels and all the others parameters.
Conclusion:
These findings suggest that the role of endocan in the pathogenesis of pre-eclampsia was not related to pre-eclampsia; hence, further studies are needed to investigate the role of endocan in the pathogenesis of pre-eclampsia.
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