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Related Experiment Video

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Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
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[Tetanus can still be found in Denmark].

Mathias Amdi Hertz1, Signe Maj Sørensen

  • 1Kløvervænget 26D, st. 1, 5000 Odense. mathias.hertz@gmail.com.

Ugeskrift for Laeger
|December 24, 2014
PubMed
Summary

A 78-year-old woman developed severe tetanus (lockjaw) after a minor wound. Despite intensive care, she fully recovered, highlighting the importance of timely vaccination and treatment for Clostridium tetani infections.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Toxicology

Background:

  • Tetanus, or lockjaw, is a serious bacterial infection caused by Clostridium tetani toxins.
  • Clostridium tetani typically enters the body through contaminated wounds, leading to neuromuscular dysfunction.

Observation:

  • A case study of an unvaccinated, previously healthy 78-year-old woman with tetanus is presented.
  • Symptoms included hoarseness, dyspnea, trismus, and severe muscle cramps following a minor palm injury.

Findings:

  • The patient received tetanus vaccination post-trauma but no immunoglobulins.
  • She required 33 days of intensive care due to respiratory insufficiency and painful muscle spasms.

Implications:

  • This case underscores the risk of tetanus in unvaccinated individuals, even after seemingly minor trauma.

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  • Prompt and appropriate medical intervention, including supportive care in intensive settings, is crucial for recovery from severe tetanus.
  • Highlights the critical role of tetanus vaccination in preventing severe outcomes from Clostridium tetani exposure.