Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same author

A STAT1/ETC/GBP1 axis represents a potential therapeutic target for noncommunicable granulomatous skin disease.

Science advances·2026

Same author

Synthesis of Cyclopropene-Modified Fatty Acids Allows Single-Cell Quantification of Uptake by Immune Cells.

Angewandte Chemie (International ed. in English)·2026

Same author

Comprehensive Lipidomic Profiling Reveals Distinct Metabolic Remodeling during Differentiation of Human Monocyte-Derived Macrophages.

Journal of proteome research·2026

Same author

Cardiolipin preserves T<sub>reg</sub> metabolic fitness and immune homeostasis in the gut.

Nature metabolism·2026

Same author

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026

Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026

Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026

Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026

Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026

Same journal

Immunity: from specificity to physiological integration.

Nature reviews. Immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Dendritic cell metabolism.

Edward J Pearce¹, Bart Everts²

¹Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Nature Reviews. Immunology

|December 24, 2014

Summary

This summary is machine-generated.

Dendritic cells (DCs) use signaling pathways to initiate immune responses. Recent research reveals these pathways also regulate metabolic pathways, integrating cellular needs for DC activation and function.

More Related Videos

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

Related Experiment Videos

Last Updated: Apr 19, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

Area of Science:

Immunology
Cell Biology
Metabolism

Background:

Dendritic cells (DCs) are crucial immune cells that bridge innate and adaptive immunity.
Advances in understanding DC receptor and signaling systems have been significant over the last 15 years.
DCs initiate immune responses upon detecting pathogens or danger signals.

Purpose of the Study:

To review the emerging field of dendritic cell immunometabolism.
To provide an integrated perspective on how metabolic pathways are linked to DC immune functions.
To highlight the interplay between DC activation and cellular metabolic requirements.

Main Methods:

This is a review article, synthesizing existing research.
Focuses on analyzing signaling pathways and their impact on gene expression and metabolism in DCs.
Integrates findings from immunology and metabolic research.

Main Results:

DC activation involves not only changes in immune function genes but also metabolic pathway alterations.
Signaling pathways controlling DC immune functions also influence metabolic pathways.
Metabolism is integral to meeting the cellular demands of DC activation.

Conclusions:

DC immunometabolism is a critical and rapidly developing area of research.
Understanding DC metabolism provides insights into immune cell activation and function.
An integrated view of DC immunometabolism is essential for future research.