Related Experiment Video

Updated: Apr 19, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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[Medical therapies for locally advanced/metastatic kidney cancer]

Mehdi Afrit1, Yosra Yahyaoui1, Aderrazek Bouzouita2

  • 1Hôpital Abderrahmane Mami, service d'oncologie médicale, 1005 Tunis, Tunisie.

Presse Medicale (Paris, France : 1983)
|December 24, 2014
PubMed
Abstract

Insights

Targeted therapies have demonstrated significant benefits in improving progression-free survival for patients with advanced or metastatic renal cell cancer. These molecularly-driven treatments are now integral to managing this disease.

Area of Science:

  • Oncology
  • Medical Research

Context:

  • Locally advanced and/or metastatic renal cell carcinoma (RCC) presents significant treatment challenges.
  • The evolution of targeted therapies has revolutionized cancer treatment paradigms.

Purpose:

  • To review and analyze international randomized trials on targeted therapies for advanced or metastatic renal cell carcinoma.
  • To evaluate the efficacy and benefits of targeted therapies in RCC treatment.

Summary:

  • A review of publications from 2000-2014 focused on large randomized trials.
  • Trials demonstrated that targeted therapies significantly improve progression-free survival in clear cell carcinomas.
  • Advances in molecular biology underpin the development and success of these therapies.

Impact:

  • Targeted therapies have established a crucial role in the management of metastatic renal cell carcinoma.
  • This review highlights the clinical benefits of molecularly-targeted agents in RCC.
  • Future research can build upon these findings to further optimize RCC treatment strategies.

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