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[Effect of ethanol on synaptosomal membrane potential in the rat brain]
W Oda-Kurio1, R Fukunaga, C Inagaki
1Department of Biology, Kyoto Pharmaceutical University, Japan.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|August 1, 1989
Abstract:
The membrane potential of rat brain synaptosomes was depolarized by ethanol at concentrations of over 0.8-1.6%. This ethanol-induced depolarization was augmented by 4-aminopyridine (4-AP) or the gluconate- -medium, but not affected by tetrodotoxin, choline-Cl, NH4Cl, picrotoxin, ethacrynic acid, furosemide or SCN- -medium. The ethanol-induced depolarization was augmented by 4-AP in Cl- - or gluconate- -medium, but not in SCN- -medium. These findings suggest that ethanol depolarizes the synaptosomal membrane potential through potassium and anion-related mechanisms, probably through potassium channels.