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Updated: Apr 19, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
Whole-body MRI as an unconventional diagnostic tool in a pediatric patient with systemic infection
Paolo Picco1, Aldo Naselli1, Giovanna Pala1
12nd Pediatric Division, IRCCS Giannina Gaslini Insitute and University of Genoa, Genova, Italy.
Abstract:
Anaplasma phagocytophilum, an obligate intracellular bacterium, is the causative agent of human granulocytic anaplasmosis (HGA), a tickborne infection usually manifesting as fever, malaise, cytopenia, spleen enlargement, and hepatitis. Herein, we report a case of a 14-year-old girl with HGA whose whole-body magnetic resonance imaging (MRI) disclosed an unusual picture characterized by small, widespread punctuate millimetric nodules, hypointense on T1-weighted and hyperintense on STIR sequences. This firstly reported finding may represent an alternative tool for identifying atypical infectious diseases.
Insights
Human granulocytic anaplasmosis (HGA), a tickborne illness, can present unusually. Whole-body MRI revealed small, widespread nodules in a 14-year-old girl, suggesting a new diagnostic approach for atypical infections.
Area of Science:
- Infectious Diseases
- Radiology
- Microbiology
Background:
- Anaplasma phagocytophilum causes human granulocytic anaplasmosis (HGA), a significant tickborne illness.
- HGA typically presents with fever, malaise, cytopenia, splenomegaly, and hepatitis.
Observation:
- A case of HGA in a 14-year-old girl is presented.
- Unusual findings on whole-body magnetic resonance imaging (MRI) were observed.
Findings:
- The MRI revealed small, widespread, punctuate millimetric nodules.
- These nodules were hypointense on T1-weighted and hyperintense on STIR sequences.
Implications:
- This MRI pattern is a novel finding in HGA.
- This imaging characteristic may aid in diagnosing atypical infectious diseases.
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