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Updated: Apr 19, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-defined polymers for the delivery of oligonucleotides

Taavi Lehto1, Ernst Wagner

  • 1Pharmaceutical Biotechnology, Department of Pharmacy and Center for Nanoscience (CeNS), Ludwig-Maximilians-University, Munich, Germany.

Nanomedicine (London, England)
|December 24, 2014
PubMed

Insights

Sequence-defined polymers offer a promising solution for delivering therapeutic oligonucleotides (ONs), overcoming bioavailability challenges and advancing gene-targeting therapies for clinical use.

Area of Science:

  • Biomaterials Science
  • Gene Therapy
  • Polymer Chemistry

Background:

  • Short synthetic oligonucleotides (ONs) show high specificity for gene expression targeting, holding significant therapeutic potential.
  • Clinical application of ONs is limited by poor bioavailability due to extracellular and intracellular barriers.
  • Existing cationic polymers for ON delivery are heterogeneous and unsuitable for clinical use.

Purpose of the Study:

  • To review recent advancements in sequence-defined polymers for oligonucleotide delivery.
  • To highlight the potential of defined polymers in overcoming ON bioavailability issues.

Main Methods:

  • Review of literature on sequence-defined polymers and their application in oligonucleotide delivery.
  • Analysis of the structural advantages of sequence-defined polymers over classical polymers.

Main Results:

  • Sequence-defined polymers offer a defined structure, addressing limitations of heterogeneous classical polymers.
  • These advanced polymers show promise in enhancing the delivery and bioavailability of short ONs.

Conclusions:

  • Sequence-defined polymers represent a significant advancement for the clinical translation of oligonucleotide therapeutics.
  • The development of well-defined delivery vectors is crucial for unlocking the full potential of gene-targeting ONs.
Keywords:
cell-penetrating peptidesnonviral deliveryoligonucleotide deliveryoligonucleotidesprecise polymerssequence-defined polymerssiRNA deliverysolid-phase peptide synthesistargeted delivery

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