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Updated: Apr 19, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Solid-supported hydrazone of 4-(4'-formyl-3'-methoxyphenoxy)butyric acid as a new traceless linker for solid-phase
Sergei Okorochenkov1, Kristyna Burglova, Igor Popa
1Department of Organic Chemistry, Faculty of Science, Palacký University , 771 46 Olomouc, Czech Republic.
Abstract:
The use of a hydrazine derived from a backbone amide linker as a new hydrazone-based traceless linker for solid-phase organic synthesis is described. The stability of the linker was tested under various conditions, including treatment with acids, bases, and borohydrides. Final compounds can be released by selective cleavage using trimethylsilanolate. To demonstrate the versatility of the linker, the synthesis of a model compound under various reaction conditions was performed with good results.
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