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Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733.

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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Noncoding RNAs in diabetes vascular complications.

Cristina Beltrami¹, Timothy G Angelini², Costanza Emanueli³

¹National Heart and Lung Institute, Imperial College of London, London, UK.

Journal of Molecular and Cellular Cardiology

|December 24, 2014

Summary

Noncoding RNAs (ncRNAs) are key regulators in diabetes complications. This review explores their role in vascular damage and potential as biomarkers and therapeutic targets for diabetes.

Keywords:

Biomarkers Bone marrow-derived cells Diabetes Extracellular vesicles Long noncoding RNAs MicroRNAs Vascular cells

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Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

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Published on: March 8, 2018

Area of Science:

Molecular Biology
Genetics
Endocrinology

Background:

Diabetes mellitus is a prevalent metabolic disorder causing widespread vascular damage and complications.
Diabetic patients exhibit impaired vascular repair and poor outcomes from revascularization procedures.
The molecular mechanisms of diabetic vascular complications and effective therapeutic targets remain incompletely understood.

Purpose of the Study:

To review the roles of noncoding RNAs (ncRNAs) in the vascular complications of diabetes.
To discuss the potential of ncRNAs as diagnostic, prognostic, and predictive biomarkers in diabetes.
To explore therapeutic strategies targeting ncRNAs for diabetes treatment.

Main Methods:

Literature review of ncRNAs in diabetes vascular complications.
Analysis of current research on microRNAs (miRNAs) and long noncoding RNAs (lncRNAs).
Discussion of ncRNA-based biomarkers and therapeutic interventions.

Main Results:

ncRNAs, including miRNAs and lncRNAs, are emerging as critical regulators of gene expression in vascular health and disease.
Dysregulation of specific ncRNAs contributes to the pathogenesis of diabetic vascular complications.
ncRNAs show promise as novel biomarkers and therapeutic targets for diabetes.

Conclusions:

ncRNAs play significant roles in the development and progression of diabetes-associated vascular complications.
Targeting ncRNAs offers potential for developing new diagnostic tools and therapeutic strategies for diabetes.
Further research into ncRNAs is crucial for advancing diabetes care.