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Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow
1Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Investigative Ophthalmology & Visual Science
|November 1, 1989
Abstract:
We report a significant decrease in intraocular pressure after intravitreal injection of atrial natriuretic peptide (AP). There is also an increase in cGMP in iris-ciliary body preparations after exposure to physiologic concentrations of AP in vitro. We present evidence that after intravitreal AP administration there is a decrease in aqueous humor flow associated with the decrease in intraocular pressure. The changes in aqueous humor flow were estimated by automated fluorophotometry and aqueous humor ascorbate concentrations.