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Increased plasma beta-endorphin levels in hereditary angioedema
R Perricone1, C Moretti, C De Carolis
1Dipartimento Chirurgico, II University of Rome, Tor Vergata, Italy.
Immunopharmacology
|September 1, 1989
Summary
Patients with hereditary angioneurotic edema exhibit significantly elevated beta-endorphin (BE) and beta-lipotropin (BLPH) levels, particularly during attacks. This suggests altered pro-opiomelanocortin cell activity in these individuals.
Area of Science:
- Neuroendocrinology
- Immunology
- Biochemistry
Background:
- Hereditary angioneurotic edema (HANE) is linked to stress and acute episodes.
- The neuroendocrine system may be affected by recurrent HANE attacks.
- Immune system and endogenous opioid pathways are closely interconnected.
Purpose of the Study:
- To investigate plasma beta-endorphin (BE) and beta-lipotropin (BLPH) concentrations in HANE patients.
- To compare BE and BLPH levels during acute attacks and symptom-free periods.
- To explore the relationship between HANE, stress, and the neuroendocrine system.
Main Methods:
- HPLC-RIA coupled method for measuring plasma BE and BLPH.
- Study included 28 HANE patients (21 immunochemical, 7 functional) and 13 chronic urticaria controls.
- Measurements were taken during acute attacks and symptom-free intervals.
Main Results:
- Plasma BE and BLPH concentrations were dramatically increased during HANE attacks.
- Many patients displayed very high BE levels during symptom-free periods, with elevated BLPH and ACTH.
- The BLPH/BE ratio indicated potential alterations in peptide turnover.
Conclusions:
- HANE patients exhibit modified pro-opiomelanocortin-synthesizing cell activity.
- This modification may lead to massive BE release from pituitary stores.
- Increased peptide turnover is suggested by the observed BLPH/BE ratios.