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Published on: October 27, 2014
Systematic evaluation of bevacizumab in recurrent ovarian cancer treatment
Shan-Shan Ding1, Li Li, Chun-Xia Yu
1Department of Gynecology, Affiliated Tumor Hospital of Xinjiang Medical University Urumqi, 830011, P.R. China.
Purpose:
This study aimed to evaluate the efficacy and safety of bevacizumab in the treatment of recurrent ovarian cancer.
Methods:
The Cochrane Library, MEDLINE, and EMBASE were searched. Data regarding the use of bevacizumab in recurrent ovarian cancer were collected from randomized controlled trials (RCTs). Data were evaluated with the Cochrane systematic method, and statistical analysis was performed with the RevMan 5.2 software. Two RCTs comprising a total of 845 patients were included.
Results:
Bevacizumab combined with conventional chemotherapy prolonged the progression-free survival (PFS) (hazard ratio [HR] 0.48; 95% confidence interval [CI], 0.41-0.56), without significantly altering the overall survival (OS) (HR 1.03; 95% CI 0.79-1.33). Adverse events (NCI-CTCAE v.4.0) associated with bevacizumab were ≥ grade 3 hypertension (relative risk [RR] 2.30; 95% CI 1.39-3.83) and bleeding (RR 4.76; 95% CI 1.38-16.37).
Conclusions:
Bevacizumab prolonged the PFS of patients with recurrent ovarian cancer. Additional high-quality randomized controlled trials are needed to verify these results.
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