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Updated: Apr 19, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
Published on: July 8, 2021
[Regenerative medicine of the intervertebral disc: from pathophysiology to clinical application]
Nina Henry1, Pauline Colombier2, Laurent Lescaudron1
1Inserm UMRS791-LIOAD (laboratoire d'ingénierie ostéo-articulaire et dentaire), groupe STEP (skeletal tissue engineering and physiopathology), 1, place Alexis Ricordeau, 44042 Nantes, France - Université de Nantes, UFR odontologie, 44042 Nantes, France - Université de Nantes, UFR sciences et techniques, 44042 Nantes, France.
Abstract:
A large proportion of low back pain may be explained by intervertebral disc (IVD) degeneration. Currently, the process leading to IVD degeneration highlights the pivotal role of IVD cells. The number of these cells drastically decreases and does not support a spontaneous repair of the tissue. In order to counteract IVD degeneration, regenerative medicine, based on a cell supplementation of the damaged tissue is considered as a promising approach. After a description of IVD physiopathology, we will develop the different strategies based on cell therapy and tissue engineering and currently under investigation to improve altered IVD degeneration. Finally, results from the current pre-clinical and clinical studies will be discussed.
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