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WW domain-containing oxidoreductase in neuronal injury and neurological diseases

Hsin-Tzu Chang1, Chan-Chuan Liu1, Shur-Tzu Chen1

  • 1Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Oncotarget
|December 25, 2014
PubMed

Insights

The WW domain-containing oxidoreductase (WWOX) protein, initially studied as a tumor suppressor, plays a critical role in neural development and neurological diseases. This review highlights WWOX

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • The WWOX gene encodes a WW domain-containing oxidoreductase protein, implicated in various cellular signaling pathways.
  • WWOX is located on the common fragile site FRA16D and has been investigated for its role as a tumor suppressor.
  • While WWOX's role in cancer is studied, its physiological relevance in vivo and function beyond oncology require further exploration.

Purpose of the Study:

  • To review the multifaceted roles of WWOX beyond its established function in cancer.
  • To elucidate the involvement of WWOX in neural development and its implications in neurological disorders.
  • To provide insights into WWOX-regulated neurodegeneration and its therapeutic potential.

Main Methods:

  • Comprehensive literature review of studies on WWOX function.
  • Analysis of WWOX's involvement in various signaling pathways.
  • Examination of WWOX's role in neural development, injury, and diseases.

Main Results:

  • WWOX is crucial for normal neural development and has been linked to Alzheimer's disease and neuronal injury.
  • Dysregulation of WWOX is associated with epilepsy, mental retardation, and brain developmental defects in multiple species.
  • Evidence suggests WWOX's role extends to neuroprotection and regulation of neurodegenerative processes.

Conclusions:

  • WWOX is a key player in neural development and has significant implications in neurological diseases.
  • Further research into WWOX's neuroprotective functions may offer novel therapeutic strategies for neurodegeneration.
  • Shifting focus from cancer to neurological roles reveals the broader significance of WWOX in human health.

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