Related Experiment Video
Updated: Apr 19, 2026
03:14
Author Spotlight: Enhancing Success of Ultrasound-Guided Neuraxial Anesthesia in Cases with Difficult Anatomy
Published on: January 31, 2025
2.1K
[Spinal anesthesia in high-volume, low-concentration technique for Caesarean sections : Retrospective analysis].
J Jokinen1, V Adametz, M Kredel
1Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
Der Anaesthesist
|December 25, 2014
Summary
This study evaluated a high-volume, low-concentration spinal anesthesia technique for Cesarean sections. The method proved effective, with a moderate hypotension rate and few cases requiring general anesthesia.
Area of Science:
- Anesthesiology
- Obstetric Anesthesia
Context:
- Spinal anesthesia is common for Cesarean sections.
- Minimizing side effects like hypotension is crucial.
- Optimizing local anesthetic doses is an ongoing research area.
Purpose:
- To analyze the reliability and side effects of a high-volume, low-concentration spinal anesthesia technique (isobaric bupivacaine 0.1% and sufentanil).
- This technique, using up to 12 ml, has been used at University Hospital Würzburg.
- The study aimed to assess its effectiveness and safety profile.
Summary:
- A retrospective analysis of 1368 anesthesia protocols was conducted.
- The median volume used was 9 ml (9 mg bupivacaine, 9 µg sufentanil).
- Hypotension occurred in 48.8% of cases, with no significant volume-dependent difference. Conversion to general anesthesia was rare (0.84%).
Impact:
- The high-volume, low-concentration technique is effective for spinal anesthesia in Cesarean sections.
- It demonstrates a low rate of conversion to general anesthesia and need for additional analgesia.
- Findings suggest this technique is a viable option, though further research is needed to confirm dose-response relationships.
More Related Videos
Related Concept Videos
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
2.0K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
2.0K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K
01:24General Anesthesia: Overview
1.2K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.2K
01:16Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
2.1K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
2.1K
01:24Parenteral Anesthetics: Overview
972
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
972
01:30Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
2.8K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.8K