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Inflammation01:38

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Related Experiment Video

Updated: Apr 19, 2026

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Monocyte fate in atherosclerosis.

Ingo Hilgendorf1, Filip K Swirski2, Clinton S Robbins1

  • 1From the Department of Cardiology and Angiology, Heart Center, University of Freiburg, Freiburg, Germany (I.H.); Center for Systems Biology, Massachusetts General Hospital, Boston, MA (F.K.S.); and Departments of Laboratory Medicine and Pathobiology and Immunology, Peter Munk Cardiac Centre, Toronto General Research Institute, University of Toronto, Toronto, ON, Canada (C.S.R.). ingo.hilgendorf@universitaets-herzzentrum.de clint.robbins@utoronto.ca.

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 25, 2014
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Summary

Monocytes and macrophages drive atherosclerosis, a lipid-inflammatory disease. Targeting these cells offers future cardiovascular disease treatment opportunities.

Keywords:
atherosclerosiscardiovascular diseaseinflammationmacrophagemonocyte

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Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Cell Biology

Background:

  • Atherosclerosis is a lipid-driven inflammatory disease.
  • Monocytes and macrophages are key cellular players in its development and progression.
  • Lipid-laden macrophages, or foam cells, are characteristic of atherosclerotic lesions.

Purpose of the Study:

  • To review recent advancements in understanding monocyte accumulation and differentiation in atherosclerotic lesions.
  • To highlight the phenotypic and functional complexity of monocytes/macrophages in atherosclerosis.
  • To explore the therapeutic potential of targeting these cells for cardiovascular disease prevention and treatment.

Main Methods:

  • Review of current scientific literature on monocyte and macrophage biology in atherosclerosis.
  • Synthesis of recent findings on cellular mechanisms within atherosclerotic plaques.
  • Analysis of emerging therapeutic strategies targeting monocytes/macrophages.

Main Results:

  • Significant progress has been made in understanding monocyte recruitment, differentiation, and lipid uptake in atherosclerosis.
  • Monocytes and macrophages exhibit remarkable phenotypic and functional diversity within atherosclerotic lesions.
  • These cellular complexities present unique therapeutic targets.

Conclusions:

  • Targeting atherogenic monocytes/macrophages and their products holds promise for future cardiovascular disease treatment.
  • Understanding the intricate roles of these cells is crucial for developing effective prevention and therapeutic strategies.
  • The complexity of monocyte/macrophage biology offers a rich landscape for novel interventions in cardiovascular medicine.