Related Experiment Video

Updated: Apr 19, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.6K

Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology

Ciaran Skerry1, Karen Scanlon1, Hugh Rosen2

  • 1Department of Microbiology and Immunology, University of Maryland Medical School, Baltimore.

The Journal of Infectious Diseases
|December 25, 2014
PubMed

Insights

A new study shows sphingosine-1-phosphate receptor (S1PR) agonist AAL-R can reduce lung inflammation in infant mice with pertussis. This suggests a potential host-targeted therapy for this serious bacterial infection.

Area of Science:

  • Immunology
  • Microbiology
  • Pharmacology

Background:

  • Pertussis (whooping cough) is a growing public health issue, particularly for infants.
  • Existing treatments for severe pertussis in infants are lacking.
  • Sphingosine-1-phosphate receptor (S1PR) agonists show promise for treating infectious diseases.

Purpose of the Study:

  • To investigate if S1PR agonist AAL-R can reduce lung inflammation in a mouse model of Bordetella pertussis infection.
  • To explore the potential of host-targeted therapies for pertussis.

Main Methods:

  • Utilized a murine model of Bordetella pertussis infection.
  • Administered S1PR agonist AAL-R to infected mice.
  • Assessed lung pathology and expression of inflammatory cytokines and chemokines.

Main Results:

  • AAL-R treatment significantly reduced inflammatory cytokine and chemokine expression in the lungs.
  • Attenuated lung pathology was observed in AAL-R treated mice.
  • Demonstrated a role for sphingosine-1-phosphate (S1P) signaling in pertussis pathology.

Conclusions:

  • S1PR agonism with AAL-R shows therapeutic potential for reducing inflammation in pertussis.
  • Highlights the possibility of developing host-targeted treatments for pertussis.
  • Further research into S1P signaling pathways could lead to novel pertussis therapies.
Keywords:
AAL-Rbordetellahost-directedpertussissphingosinesphingosine-1-phosphate

More Related Videos

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.1K
Non-Invasive Endotracheal Administration of Lipopolysaccharide to Induce Acute Lung Injury in Rodents04:10

Non-Invasive Endotracheal Administration of Lipopolysaccharide to Induce Acute Lung Injury in Rodents

Published on: December 5, 2025

460

Related Concept Videos

Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
59
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
8.4K
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
2.1K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
926
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
2.1K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.7K