Related Experiment Video

Updated: Apr 19, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

8.1K

An appraisal of RECQ1 expression in cancer progression

Sudha Sharma1

  • 1Department of Biochemistry and Molecular Biology, College of Medicine, Howard University , Washington, DC, USA.

Frontiers in Genetics
|December 25, 2014
PubMed

Insights

The RECQ1 helicase, often overexpressed in cancers, drives tumor cell proliferation and metastasis. Inhibiting RECQ1 may offer a new strategy to combat cancer progression and spread.

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • RECQ1 is a key human DNA helicase involved in genome stability and DNA repair.
  • Its role in cancer development and cellular transformation remains largely underappreciated.
  • RECQ1 is frequently overexpressed and amplified in various human cancers.

Purpose of the Study:

  • To investigate the biological functions of RECQ1 in cancer progression.
  • To determine the relevance of RECQ1 in cellular transformation and metastasis.
  • To explore RECQ1's potential as a therapeutic target for cancer treatment.

Main Methods:

  • In silico analysis of RECQ1 mRNA expression in NCI-60 cancer cell lines.
  • Functional studies involving the silencing of RECQ1 expression.
  • Assessment of cell proliferation, migration, and invasion assays.

Main Results:

  • RECQ1 overexpression correlates with increased cancer cell migration, invasion, and metastasis.
  • Silencing RECQ1 significantly impairs cancer cell proliferation, migration, and invasion.
  • RECQ1 regulates gene expression, particularly genes associated with cancer progression.

Conclusions:

  • RECQ1 plays a crucial role in promoting the proliferative and invasive phenotype of cancer cells.
  • Targeting RECQ1 could be a viable therapeutic strategy to inhibit tumor progression and metastasis.
  • Further research into RECQ1's functions is warranted for developing novel anti-cancer therapies.
Keywords:
RecQepithelial mesenchymal transitiongene expressionhelicasemetastasisvimentin

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.4K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.7K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
5.0K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
8.0K
Tumor Progression02:07

Tumor Progression

3.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.5K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
856
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K