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Updated: Apr 19, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Atrial fibrillation: a moving target
Jens Eckstein1, David Conen2, Michael Kühne3
1university Hospital Basel, Petersgraben 4, 4031, Basel (BS), SWITZERLAND; jens.eckstein@usb.ch.
Abstract:
Present atrial fibrillation research focuses on three different fields of interest: Basic research to gain a better understanding of the mechanisms leading to atrial fibrillation, epidemiological studies to learn about the time course, the risk factors and the complications of atrial fibrillation, and clinical trials to further improve existing treatment strategies and develop new ones. The focus of this manuscript was the mechanisms, the epidemiology, the diagnosis and the treatment of the arrhythmia per se. Therefore, the field of prevention of stroke and systemic embolism is mostly excluded for the purpose of this article.
Insights
This review covers atrial fibrillation mechanisms, epidemiology, diagnosis, and treatment. It excludes stroke prevention to focus on the arrhythmia itself.
Area of Science:
- Cardiology and Electrophysiology
- Translational Medicine
Background:
- Atrial fibrillation (AF) research spans basic mechanisms, epidemiology, and clinical trials.
- Understanding AF's complexities is crucial for effective management.
Purpose of the Study:
- To provide a comprehensive overview of atrial fibrillation.
- Focus on the mechanisms, epidemiology, diagnosis, and treatment of AF.
- Exclude stroke and systemic embolism prevention for a focused review.
Main Methods:
- Literature review and synthesis of current research.
- Analysis of epidemiological data and risk factors.
- Evaluation of diagnostic methods and treatment strategies.
Main Results:
- Atrial fibrillation research is advancing in understanding its underlying mechanisms.
- Epidemiological studies reveal significant risk factors and complications.
- Current treatments aim to improve efficacy and explore novel therapeutic approaches.
Conclusions:
- A thorough understanding of AF mechanisms, epidemiology, and diagnosis is essential.
- Optimizing treatment strategies remains a key focus in clinical practice.
- Further research is needed to refine therapeutic interventions for atrial fibrillation.
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