Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

929
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
929
Biological Effects of Radiation02:59

Biological Effects of Radiation

19.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
19.9K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

391
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Computed Tomography01:10

Computed Tomography

9.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.7K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

513
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
513

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glenohumeral septic arthritis in intravenous drug users: 10-year retrospective analysis.

Journal of clinical imaging science·2026
Same author

Dual-energy CT based scoring to estimate perfusion changes after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.

JHLT open·2026
Same author

Photon-counting Detector CT Spectral Reconstructions for Radiomics-based Liver Lesion Classification: A Multicenter Study.

Investigative radiology·2026
Same author

Characterization of body composition dynamics throughout treatment in patients with early-stage breast cancer.

NPJ breast cancer·2026
Same author

Rare case of ulnar cryptococcal osteomyelitis in a 26-year-old immunocompetent patient.

Radiology case reports·2026
Same author

Aetiology of acute respiratory infection in Vientiane, Lao PDR, from a case-control study.

Scientific reports·2026
Same journal

The Banality of Cancer: Entropy As a Third Pillar of Lung Nodule Risk Assessment.

AJR. American journal of roentgenology·2026
Same journal

A Narrow Window for Artificial Intelligence-Generated Synthetic Temporal Bone CT From MRI.

AJR. American journal of roentgenology·2026
Same journal

From Uncertainty to Actionable Management: The Isolated Abnormal Axillary Lymph Node.

AJR. American journal of roentgenology·2026
Same journal

Beyond Detection: Translating Artificial Intelligence-Driven Opportunistic Screening Into Clinical Action.

AJR. American journal of roentgenology·2026
Same journal

Navigating PSMA PET Radiopharmaceuticals: Clinical and Operational Factors.

AJR. American journal of roentgenology·2026
Same journal

From Mesenteric Ischemia to Intestinal Stroke.

AJR. American journal of roentgenology·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

15.0K

Simplifying size-specific radiation dose estimates in pediatric CT.

Ranish Deedar Ali Khawaja1, Sarabjeet Singh, Beth Vettiyil

  • 11 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 25 New Chardon St, 4th Fl, Boston, MA 02114.

AJR. American Journal of Roentgenology
|December 25, 2014
PubMed
Summary
This summary is machine-generated.

Body weight can replace manual torso diameter measurements for estimating pediatric CT radiation dose. This simplifies and speeds up size-specific dose estimates (SSDEs) in clinical practice.

Keywords:
body diameterbody weightpediatric CTsize-specific dose estimate

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Related Experiment Videos

Last Updated: Apr 19, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

15.0K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Area of Science:

  • Medical Imaging
  • Radiology
  • Radiation Dosimetry

Background:

  • Size-specific dose estimates (SSDEs) in pediatric CT require manual measurement of patient torso diameters (anteroposterior, lateral, effective).
  • These manual measurements are time-consuming in clinical settings.

Purpose of the Study:

  • To evaluate body weight as a surrogate for torso diameter measurements in children undergoing CT scans.
  • To simplify and expedite the calculation of SSDEs in pediatric patients.

Main Methods:

  • Measured anteroposterior (D(AP)) and lateral (D(LAT)) torso diameters in 522 pediatric CT examinations.
  • Calculated effective diameter (D(E1)) and used automated software for a second effective diameter (D(E2)).
  • Assessed correlations between body weight, age, and measured diameters; performed prediction interval analysis.

Main Results:

  • Strong correlations were found between body weight and all measured diameters (coefficients 0.85-0.93, p < 0.0001).
  • SSDE calculated using body weight was statistically equivalent to SSDE using effective diameters (p = 0.9).
  • Correlation varied by weight and age group, with younger children (<4 years) showing strong correlations.

Conclusions:

  • Body weight is a reliable surrogate for torso diameter measurements in pediatric CT dose estimation.
  • Utilizing body weight simplifies and accelerates the clinical estimation of size-specific dose in children.