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Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the

Rinske Loeffen1, Kristien Winckers2, Ian Ford3

  • 1Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands. rinske.loeffen@maastrichtuniversity.nl.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|December 26, 2014
PubMed

Insights

Decreased thrombin generation predicts stroke in older adults at risk for vascular disease. This study found a significant inverse association between thrombin generation and stroke, but not consistently with coronary heart disease.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Geriatrics

Background:

  • Hypercoagulability is implicated in atherosclerosis and atherothrombosis.
  • Thrombin plays a key role in coagulation and arterial disease mechanisms.

Purpose of the Study:

  • To investigate the association between thrombin generation and cardiovascular events in elderly patients.

Main Methods:

  • The study analyzed plasma thrombin generation in 4,932 elderly participants (70-82 years) from the PROSPER cohort.
  • Participants had pre-existing vascular disease or risk factors.

Main Results:

  • A delayed and decreased thrombin generation was significantly associated with an increased risk of stroke (HR 0.71 for peak height, 0.68 for potential).
  • Thrombin generation was comparable between subjects with and without incident coronary heart disease (CHD).
  • An increased normalized peak height was the only significant predictor for incident CHD (HR 1.17).

Conclusions:

  • Reduced thrombin generation is a strong, independent predictor of stroke in at-risk elderly individuals.
  • No consistent association was found between thrombin generation and incident coronary heart disease.
Abstract

Keywords:
BiomarkersBloodCardiovascularClinical trialsEpidemiology

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