Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.7K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.7K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.1K
4.1K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial Dynamics as Determinants of Cancer Drug Resistance: A Systematic Review.

Current cancer drug targets·2026
Same author

The Mutational Landscape of Angiosarcoma: Challenges and Opportunities to Design Management Strategies.

Current molecular medicine·2026
Same author

Integrating microbial bioremediation, multi-omics, and emerging technologies for polycyclic aromatic hydrocarbon (PAHs) detoxification.

Journal of microbiological methods·2026
Same author

The Role of Mitochondrial Ion Channels in the Evolution of Anticancer Drug Resistance.

Current protein & peptide science·2026
Same author

Phosphatidylethanolamine: Structural Component and Beyond.

Current molecular medicine·2026
Same author

Artificial Intelligence in the Management of One Health: An Update.

Current molecular medicine·2025

Related Experiment Video

Updated: Apr 19, 2026

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine
07:46

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine

Published on: July 28, 2023

4.8K

Induced Pluripotent Stem Cells from Nonhuman Primates.

Anuja Mishra1, Zhifang Qiu1, Steven L Farnsworth1

  • 1South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|December 26, 2014
PubMed
Summary

Induced pluripotent stem cells (iPS cells) from nonhuman primates (NHPs) are vital for comparative biology and regenerative medicine. Reprogramming NHP cells requires adapting human cell protocols due to species-specific differences.

Keywords:
Induced pluripotent stem cellsMarmosetNonhuman primatesReprogrammingRetrovirusesTeratoma

More Related Videos

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

13.7K
Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

20.5K

Related Experiment Videos

Last Updated: Apr 19, 2026

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine
07:46

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine

Published on: July 28, 2023

4.8K
Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

13.7K
Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

20.5K

Area of Science:

  • Stem cell biology
  • Comparative genomics
  • Regenerative medicine

Background:

  • Nonhuman primate induced pluripotent stem cells (NHP iPS cells) hold significant potential in biological research and therapeutic applications.
  • NHPs are evolutionarily close to humans, making their iPS cells valuable for studying human biology and disease.
  • NHP iPS cells are crucial for translational research in cell therapy, bridging preclinical studies and human clinical trials.

Purpose of the Study:

  • To highlight the unique roles and applications of induced pluripotent stem cells derived from nonhuman primates (NHPs).
  • To emphasize the utility of NHP iPS cells in comparative primate biology and translational regenerative medicine.
  • To outline the reprogramming process and necessary modifications for NHP somatic cells.

Main Methods:

  • Reprogramming of nonhuman primate somatic cells to generate induced pluripotent stem cells.
  • Adaptation of established human cell reprogramming protocols to accommodate species-specific differences in NHPs.
  • Generation of differentiated cell derivatives from NHP iPS cells for experimental use.

Main Results:

  • NHP iPS cells can be generated using conditions similar to those for human cells.
  • Significant modifications to human cell reprogramming protocols are necessary for successful NHP iPS cell generation.
  • Differentiated derivatives from NHP iPS cells are valuable tools for comparative biology and translational cell therapy.

Conclusions:

  • NHP iPS cells are essential for advancing our understanding of primate biology and developing novel cell-based therapies.
  • Successful reprogramming of NHP somatic cells necessitates careful consideration and adaptation of existing human protocols.
  • The use of NHP iPS cells offers a powerful platform for preclinical testing and validation of cell therapies.