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The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
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Neuropsychiatric genetics in developing countries: Current challenges.

Diego A Forero1, Alberto Vélez-van-Meerbeke1, Smita N Deshpande1

  • 1Diego A Forero, Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá 110231, Colombia.

World Journal of Psychiatry
|December 26, 2014
PubMed
Summary
This summary is machine-generated.

Neuropsychiatric disorders (NPDs) significantly impact global health, especially in low and middle-income countries (LMICs). Advancing NPD genetics research in LMICs requires increased funding and local research programs for better diagnostics and interventions.

Keywords:
Mental healthNeurogeneticsNeurosciencesPsychiatric geneticsPublic health

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Area of Science:

  • Neuroscience
  • Genetics
  • Public Health

Background:

  • Neuropsychiatric disorders (NPDs) represent a substantial global health burden, disproportionately affecting low and middle-income countries (LMICs).
  • Genetic factors are increasingly recognized as significant contributors to the risk of developing numerous NPDs.
  • There is a notable scarcity of neuropsychiatric genetics research originating from LMICs.

Purpose of the Study:

  • To highlight critical challenges and opportunities for advancing neuropsychiatric genetics research within LMICs.
  • To emphasize the necessity of engaging policymakers and funding bodies to secure adequate research support.
  • To advocate for the development of sustainable, locally-driven research programs in LMICs.

Main Methods:

  • This editorial discusses existing literature and expert perspectives on the state of neuropsychiatric genetics research in LMICs.
  • It emphasizes the importance of scientific advocacy and policy engagement.
  • It proposes the establishment of robust, local research infrastructure.

Main Results:

  • Limited research from LMICs hinders a comprehensive understanding of NPD genetics globally.
  • Adequate funding and dedicated local research programs are crucial for progress.
  • Developing local capacity can lead to tailored, affordable interventions for LMICs.

Conclusions:

  • Neuropsychiatric genetics research is vital for global mental health, not just for developed nations.
  • Investing in LMIC-based research is essential for equitable advancements in understanding and treating NPDs.
  • Sustainable research programs in LMICs can yield context-specific diagnostic and therapeutic solutions.