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Malaria-associated hypoglycaemia in children

Lola Madrid1, Miguel Lanaspa, Sónia Amós Maculuve

  • 1Centro de Investigação em Saúde de Manhiça (CISM), Rua 12, Cambeve, Vila de Manhiça, CP1929, Maputo, Mozambique.

Expert Review of Anti-Infective Therapy
|December 27, 2014
PubMed

Insights

Hypoglycemia is a common, life-threatening complication in children with malaria, especially in developing nations. Understanding its causes and impact is crucial for improving patient outcomes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Global Health

Background:

  • Hypoglycemia is a frequent complication in hospitalized children in developing countries.
  • It is a defining feature of severe malaria, associated with high case fatality rates (CFR).
  • The complication's prevalence may be underestimated due to its often subtle clinical presentation.

Purpose of the Study:

  • To review the existing literature on hypoglycemia in malaria patients.
  • To elucidate the incidence, risk factors, and consequences of this complication.
  • To enhance the understanding of this significant malaria-associated condition.

Main Methods:

  • Literature review of published studies.
  • Analysis of data concerning hypoglycemia in malaria patients.
  • Synthesis of information on incidence, risk factors, and outcomes.

Main Results:

  • Hypoglycemia is a common and serious complication of malaria, particularly in pediatric populations in resource-limited settings.
  • The etiology is multifactorial and not fully understood.
  • Routine screening and treatment face challenges due to limited resources in developing countries.

Conclusions:

  • Hypoglycemia is a critical, potentially under-recognized complication of malaria with severe consequences.
  • Further research is needed to fully understand its multifactorial etiology.
  • Improved strategies for screening and management are essential, despite resource limitations in endemic areas.

Keywords:
childrencontinuous glucose monitorglucose consumptionglucose homeostasishyperinsulinemiahypoglycemiamalariasublingual glucose

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