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Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

Niki Chondrogianni1, Konstantinos Voutetakis1, Marianna Kapetanou1

  • 1National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.

Ageing Research Reviews
|December 27, 2014
PubMed

Insights

Activating the proteasome, a key cellular machinery, can slow aging and combat age-related diseases. This review explores proteasome activation studies across species and diseases, highlighting its potential for extending lifespan.

Area of Science:

  • Cellular Biology
  • Gerontology
  • Biochemistry

Background:

  • Aging involves macromolecular damage accumulation, particularly in proteins, leading to proteostasis failure.
  • Dysfunction of major cellular proteolytic systems, the proteasome and lysosome, is linked to aging and age-related diseases.
  • Proteasome activation, through genetic or chemical means, is associated with extended lifespan and delayed disease progression.

Purpose of the Study:

  • To review proteasome activation studies in various species and cellular models.
  • To examine the effects of proteasome activation on aging and longevity.
  • To summarize findings on proteasome activation in age-related diseases and progeroid syndromes.

Main Methods:

  • Literature review of studies on proteasome activation.
  • Analysis of data from genetic manipulation and compound treatments.
  • Synthesis of findings across different species and disease models.

Main Results:

  • Proteasome activation can extend lifespan and decelerate aging.
  • Dysfunctional proteasomes are implicated in aging and age-related pathologies.
  • Proteasome activation strategies show promise in diverse models.

Conclusions:

  • Targeting proteasome activation is a viable strategy for combating aging and age-related diseases.
  • Further research into proteasome activation mechanisms can yield therapeutic benefits.
  • Understanding proteasome function is crucial for promoting healthspan and longevity.
Keywords:
Age-related diseasesAgingLongevityProteasome activationSenescenceUbiquitin–proteasome system

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