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Progressive decrease in the potential usefulness of meningococcal serogroup B vaccine (4CMenB, Bexsero®) in Gipuzkoa,
Emilio Pérez-Trallero1, Olatz Esnal2, José M Marimón3
1Microbiology Service and Reference Laboratory for Meningococcal Infections of the Basque Country, Hospital Donostia-IIS Biodonostia, San Sebastián, Spain; Biomedical Research Centre Network for Respiratory Diseases (CIBERES), San Sebastián, Spain; Faculty of Medicine, University of the Basque Country UPV/EHU, San Sebastián, Spain.
Plos One
|December 27, 2014
Summary
The 4CMenB vaccine
Area of Science:
- Vaccinology
- Microbiology
- Epidemiology
Background:
- Vaccine effectiveness depends on coverage of circulating strains.
- The 4CMenB vaccine targets Neisseria meningitidis serogroup B.
- Strain variability can impact vaccine protection over time.
Purpose of the Study:
- To assess changes in vaccine protection against meningococcal strains.
- To analyze antigen coverage of the 4CMenB vaccine in Southern Europe.
- To evaluate vaccine effectiveness trends from 2008 to 2013.
Main Methods:
- Analysis of allelic distribution of vaccine antigens (FHbp, Nhba, NadA, PorA).
- Characterization of 82 invasive Neisseria meningitidis isolates (serogroups B and non-B).
- Calculation of predicted vaccine protection over the study period.
Main Results:
- Overall predicted protection by 4CMenB was 61.8% for serogroup B and 50% for non-B strains.
- Predicted protection decreased to 42.1% for serogroup B isolates between 2012-2013.
- A significant decreasing trend in predicted protection was observed (p=0.03).
- This decline correlated with a decrease in specific clonal complexes targeted by the vaccine.
Conclusions:
- The 4CMenB vaccine's predicted effectiveness against circulating meningococcal strains has declined.
- Changes in meningococcal epidemiology, specifically clonal complex distribution, impact vaccine coverage.
- Ongoing surveillance is crucial to monitor vaccine effectiveness and adapt vaccination strategies.
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