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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Apr 19, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Mining CK2 in cancer.

Charina E Ortega1, Yoshua Seidner1, Isabel Dominguez1

  • 1Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, 02118, United States of America.

Plos One
|December 27, 2014
PubMed
Summary
This summary is machine-generated.

Protein kinase CK2 (CK2) plays a role in cancer development. This study found CK2 gene upregulation in tumors and linked its expression to patient survival, suggesting CK2 as a potential cancer biomarker and therapeutic target.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein kinase CK2 (CK2) is implicated in cell growth, proliferation, and apoptosis, functioning as an oncogene.
  • Elevated CK2α protein levels are observed in many human tumors, but information on CK2α' and CK2β subunits and gene transcript expression is limited.
  • Understanding CK2 transcript expression is crucial for its role in cancer progression and therapeutic targeting.

Purpose of the Study:

  • To investigate the expression of CK2 gene transcripts in primary tumor tissues of the six most lethal cancers in the USA.
  • To analyze the correlation between CK2 expression levels and patient overall survival in breast, ovarian, and lung cancers.
  • To evaluate CK2 as a potential biomarker and therapeutic target in cancer.

Main Methods:

  • Utilized the Oncomine database to examine CK2 transcript expression in primary tumor tissues.
  • Employed the Kaplan-Meier Plotter database to assess the relationship between CK2 expression and patient survival.
  • Focused on the six highest mortality cancers in the USA and specific cancers like breast, ovarian, and lung.

Main Results:

  • Widespread upregulation of CK2 gene transcripts was observed in primary tumor tissues.
  • Underexpression of CK2α' transcripts and increased CK2β transcripts were noted in specific tumor types and invasive cancers.
  • Deregulation of CK2 transcripts was identified in tumor precursors, with significant correlations between CK2 expression and patient survival.

Conclusions:

  • CK2 gene expression is frequently altered in various human cancers.
  • CK2 subunits (CK2α, CK2α', CK2β) exhibit complex expression patterns in tumors and precursors.
  • CK2 expression levels correlate with patient survival, reinforcing its potential as a cancer biomarker and therapeutic target.