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Updated: Apr 19, 2026

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Synthesis, anti-oxidant activity, and biodegradability of a novel recombinant polysaccharide derived from chitosan
Ming Guo1, Yanfei Ma2, Chunge Wang1
1Department of Chemistry, Zhejiang Agricultural & Forestry University, Hangzhou, Zhejiang, 311300, China; National Engineering and Technology Research Center of Wood-based Resources Comprehensive Utilization, Zhejiang Agricultural & Forestry University, Hangzhou, Zhejiang, 311300, China.
Abstract:
A novel recombinant polysaccharide (RP) based on polysaccharide-disaccharide was synthesized from oligo-chitosan (oligo-CS) and reducing lactose using Maillard reaction with the yield of 85.1%. Chemical structure and thermal stability of RP was characterized by Fourier transform infrared spectrum (FT-IR), solid-state nuclear magnetic resonance spectroscopy (CP/MAS (13)C-NMR), and thermo gravimetric analysis (TGA). The anti-oxidant activity of RP was preliminarily investigated by its scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Biodegradability of RP was also examined by the observation of growth status of Aspergillus niger colony. It was demonstrated that RP achieved excellent radical-scavenging efficiency (>80%) at high concentrations of DPPH and its scavenging ability was superior to that of CS, suggesting that anti-oxidant property of CS was remarkably promoted by chemical modification with reducing lactose via Maillard reaction. And biodegradation test revealed that RP had better biodegradability than CS.
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