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[Serotypes and antibiotic resistance patterns in beta-hemolytic Streptococcus agalactiae isolates in colonized

María Del Carmen Liébana-Martos1, Jorge Cabrera-Alavargonzalez1, Javier Rodríguez-Granger1

  • 1Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, España.

Enfermedades Infecciosas Y Microbiologia Clinica
|December 28, 2014
PubMed

Insights

Streptococcus agalactiae (GBS) serotype distribution and antibiotic resistance are crucial for developing effective vaccines. Serotype V showed the most antimicrobial resistance in this study.

Area of Science:

  • Microbiology
  • Vaccinology
  • Epidemiology

Background:

  • Neonatal disease caused by Streptococcus agalactiae (GBS) is currently managed via prenatal screening and antibiotic prophylaxis.
  • Understanding GBS serotype distribution is essential for developing alternative preventive strategies like polysaccharide vaccines.

Purpose of the Study:

  • To determine the distribution of capsular serotypes among GBS strains from pregnant women and neonates.
  • To assess the antimicrobial resistance patterns of these GBS strains.

Main Methods:

  • 188 GBS strains from pregnant women and 24 from neonates were analyzed.
  • Susceptibility testing for penicillin, erythromycin, and clindamycin was performed.
  • Capsular serotyping utilized latex agglutination and PCR methods.

Main Results:

  • High agreement (80.8%–95.8%) was observed between latex agglutination and PCR for serotyping.
  • Antimicrobial resistance rates were higher in strains from pregnant women (erythromycin 16.5%, clindamycin 10.1%) compared to neonatal strains (erythromycin 8.3%, clindamycin 4.1%).
  • Serotype iii was most frequent, while serotype v was most associated with antimicrobial resistance.

Conclusions:

  • Epidemiological surveillance of GBS serotypes and antibiotic sensitivity is vital.
  • Sensitive and specific methods are needed for ongoing monitoring of invasive GBS disease.
  • This data supports the need for GBS vaccine development considering serotype prevalence and resistance.
Abstract

Keywords:
Enfermedad neonatalNeonatal diseaseSerotipoSerotypeStreptococcus agalactiae

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