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Related Concept Videos

Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Robust and versatile pectin-based drug delivery systems.

T Marras-Marquez1, J Peña2, M D Veiga-Ochoa1

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.

International Journal of Pharmaceutics
|December 28, 2014
PubMed
Summary
This summary is machine-generated.

New pectin hydrogels were developed for oral drug delivery, incorporating surfactants to control release. Strategies like blending with agarose or freeze-drying improved handling and altered drug release kinetics for the model drug tolbutamide.

Keywords:
Freeze-dryingHydrogelsKineticsOral drug deliveryPore architectureSurfactants

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Polymer Chemistry

Background:

  • Pectin hydrogels offer versatile platforms for oral drug delivery.
  • Tailoring drug release profiles is crucial for effective oral administration.
  • Challenges exist in handling surfactant-loaded hydrogels and managing drugs with poor solubility.

Purpose of the Study:

  • To prepare and characterize pectin-based hydrogel vehicles for oral administration.
  • To investigate the influence of surfactants on drug release patterns.
  • To develop strategies for improving the manipulability and drug release behavior of pectin hydrogels.

Main Methods:

  • Preparation of pectin-based hydrogels.
  • Incorporation of various surfactants (Pluronic, Tween, Na Lauryl sulphate).
  • Strategies to improve hydrogel handling: blending with agarose and freeze-drying.
  • Drug release studies using tolbutamide as a model drug.
  • Analysis of release kinetics using Higuchi and Korsmeyer-Peppas models.

Main Results:

  • Surfactant incorporation into pectin hydrogels presented handling challenges.
  • Blending with agarose resulted in robust, easily handled hydrogels.
  • Freeze-drying created porous structures that influenced drug release.
  • Tolbutamide release followed Higuchi model in fresh matrices and Korsmeyer-Peppas in freeze-dried ones.

Conclusions:

  • Pectin hydrogels can be modified with surfactants for tailored drug release.
  • Agarose blending and freeze-drying are effective strategies to overcome handling issues and modulate release.
  • The microstructure of freeze-dried hydrogels significantly impacts drug release mechanisms.