Related Experiment Video
Updated: Apr 19, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
[Significance of chromosome 7 abnormalities in myeloid malignancies]
Wen-Hui Shi1, Xiao Li1, Chun-Kang Chang1
1Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China.
Abstract:
Chromosome 7 abnormalities are the most common cytogenetic alterations found in myeloid malignancies. Myeloid malignancies exhibiting monosomy 7/del (7q) have been confirmed to associate with high susceptibility to infections, poor response to chemotherapy, and short survival time, so speculating that chromosome 7 has important tumor suppressor genes. Commonly deleted segments (such as 7q22) of chromosome 7 have been identified by FISH and other technologies. Genes (EZH2, MLL5, DOCK4, SAMD9L/SAMD9) located in commonly deleted segments of 7q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7/del(7q).
Related Concept Videos
Abnormal Proliferation
Karyotyping
Differentiation of Common Myeloid Progenitor Cells

