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Microscopic analysis of molar--incisor malformation
Hyo-Seol Lee1, Soo-Hyun Kim1, Seong-Oh Kim2
1Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|December 30, 2014
Summary
Molar-incisor malformation (MIM) involves unique molar root issues. This study found abnormal dental tissue and cells in MIM teeth, suggesting developmental origin from the pulp and follicle.
Area of Science:
- Dentistry
- Developmental Biology
- Oral Pathology
Background:
- Molar-incisor malformation (MIM) is a recently identified dental anomaly.
- It is characterized by distinct root malformations in permanent first molars.
Observation:
- Microstructure of four MIM teeth was analyzed using micro-CT, H&E, immunohistochemistry, and SEM.
- The pulpal floor exhibited three distinct layers: upper, middle, and lower.
Findings:
- The middle pulpal floor layer contained amorphous hard tissues and hyperactive cells.
- These cells were positive for dentin sialoprotein and osteocalcin, but negative for collagen XII.
Implications:
- The findings suggest MIM arises from abnormal differentiation of the apical pulp and dental follicle.
- Understanding the microstructure aids in determining the etiology of this dental anomaly.
