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Decreased phosphofructokinase activity during the development of triorthocresyl-phosphate-induced delayed neuropathy
A F Hernandez1, A Pla, E Villanueva
1Department of Legal Medicine and Toxicology Service, Faculty of Medicine, University Hospital, University of Granada, Spain.
Toxicology Letters
|October 1, 1989
Abstract:
The effect of triorthocresyl phosphate on selected glycolytic enzymes (hexokinase, phosphofructokinase, glyceraldehyde 3-phosphate dehydrogenase, lactate dehydrogenase) was investigated during the development of organophosphate-induced delayed neuropathy. Only phosphofructokinase activity was decreased 15 days after treatment. The effect was dose-dependent and was observed in sciatic nerve while the brain enzyme activity was not affected.