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Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish
David Boyle1, Halis Boran, Andrew J Atfield
1School of Biomedical and Biological Sciences, Plymouth University, Plymouth, Devon, United Kingdom.
Abstract:
A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and the 96-h median lethal concentration (LC50) values were highly reproducible (coefficient of variation <0.16, n = 3 tests). Significantly lower toxicity for each NP tested (Ag, Cu, and TiO2 NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs.
