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Updated: Apr 19, 2026

Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel
Published on: January 11, 2012
Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons
Nicholas Stephanopoulos1, Ronit Freeman, Hilary A North
1Simpson Querrey Institute for BioNanotechnology, Feinberg School of Medicine and ‡Department of Neurology, Northwestern University , Chicago, Illinois 60611, United States.
Abstract:
We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson-Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.
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