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Updated: Apr 19, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
The locus C11orf30 increases susceptibility to poly-sensitization
A F S Amaral1, C Minelli, S Guerra
1Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK; MRC-PHE Centre for Environment & Health, London, UK.
Genetic variants influence allergic sensitization, with C11orf30-rs2155219 significantly increasing the risk of developing allergies to multiple allergens (poly-sensitization). This finding highlights a key genetic factor in atopy development.
Area of Science:
- Immunogenetics
- Allergology
- Population Genetics
Background:
- Genetic variants are linked to allergic sensitization, but their specificity and role in poly-sensitization remain unclear.
- Understanding genetic predispositions is crucial for managing allergic diseases.
Purpose of the Study:
- To investigate the association between 10 genetic loci and sensitization to specific allergens and poly-sensitization.
- To identify genetic factors contributing to multiple allergic sensitizations.
Main Methods:
- Utilized data from the European Community Respiratory Health Survey (ECRHS), a large multicenter population-based study.
- Assessed associations between 10 genetic loci and specific IgE levels and skin prick test results for individual allergens and poly-sensitization.
Main Results:
- The 10 studied genetic loci were associated with sensitization to various allergens in a non-specific manner.
- The C11orf30-rs2155219 locus demonstrated a significant association with poly-sensitization, doubling the risk.
- This locus showed a correlation with increased C11orf30 gene expression, potentially involved in immune regulation.
Conclusions:
- The C11orf30-rs2155219 genetic locus plays a significant role in increasing susceptibility to poly-sensitization.
- This finding suggests C11orf30 is a key genetic factor relevant to the development of atopy.
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