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Updated: Apr 19, 2026
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Somatostatin receptor expressing bilateral ovarian metastases detected by (68)Ga DOTANOC PET/CT
Saurabh Arora1, Ramya Soundararajan, Prashant Joshi
1From the Departments of *Nuclear Medicine and PET, and †Pathology, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
Bilateral ovarian metastasis from neuroendocrine tumor (NET) is uncommon. Ovarian NET could be primary or metastatic, and if it is bilateral, then the chances of metastatic disease are from 88% to 94%. Proper identification and appropriate management become necessary in such patients. Somatostatin receptor imaging by Ga-labeled DOTANOC ([1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide) PET/CT can be used for localization, staging, and restaging of NET, and it also has an impact on appropriate clinical management of patients with NET. We present here a case of somatostatin receptor expressing bilateral ovarian metastases from NET demonstrated by Ga DOTANOC PET/CT imaging.
Insights
Bilateral ovarian metastases from neuroendocrine tumors (NET) are rare but often indicate advanced disease. Gallium-DOTANOC PET/CT imaging effectively visualizes these somatostatin receptor-positive metastases, aiding clinical management.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Bilateral ovarian metastasis from neuroendocrine tumors (NET) is an uncommon presentation.
- Ovarian NET can be primary or metastatic; bilateral involvement strongly suggests metastatic disease (88-94%).
- Accurate diagnosis and management are crucial for patients with ovarian NET.
Observation:
- This case highlights bilateral ovarian metastases from NET.
- The metastases expressed somatostatin receptors.
- The findings were clearly demonstrated using Gallium-68 (Ga) DOTANOC Positron Emission Tomography/Computed Tomography (PET/CT) imaging.
Findings:
- Ga-DOTANOC PET/CT imaging successfully identified somatostatin receptor-positive bilateral ovarian metastases from NET.
- This imaging modality is valuable for the localization and staging of NET.
- The imaging findings have direct implications for patient management.
Implications:
- Somatostatin receptor imaging with Ga-DOTANOC PET/CT is a key tool for diagnosing and staging NET, particularly in cases of suspected ovarian metastasis.
- This imaging technique can guide treatment decisions and monitoring for patients with NET.
- The case underscores the utility of advanced imaging in managing rare oncological presentations.
