Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital corneal keloid.

M J Weiner1, D M Albert

  • 1Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Acta Ophthalmologica. Supplement
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

This study reviews an infant with congenital corneal opacity, aniridia, and cataract. Pathological findings suggest a congenital corneal keloid, indicating a primary ocular developmental disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment choice and quality of life in patients with choroidal melanoma.

Archives of ophthalmology (Chicago, Ill. : 1960)·1999
Same author

Primary orbital Ewing sarcoma in a middle-aged woman.

Archives of ophthalmology (Chicago, Ill. : 1960)·1999
Same author

Single-stage laryngotracheal reconstruction: the Great Ormond Street experience and guidelines for patient selection.

Archives of otolaryngology--head & neck surgery·1999
Same author

Antineoplastic effect and toxicity of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 in athymic mice with Y-79 human retinoblastoma tumors.

Archives of ophthalmology (Chicago, Ill. : 1960)·1999
Same author

The fine structure of an iridectomy specimen from a patient with latanoprost-induced eye color change.

Archives of ophthalmology (Chicago, Ill. : 1960)·1999
Same author

Ancient schwannoma of the orbit.

Archives of ophthalmology (Chicago, Ill. : 1960)·1999
Same journal

The Glaucoma Guidelines of the Swedish Ophthalmological Society.

Acta ophthalmologica. Supplement·2013
Same journal

Abstracts of the XXXX Nordic Congress of Ophthalmology. August 25-28, 2012. Helsinki, Finland.

Acta ophthalmologica. Supplement·2012
Same journal

Abstracts of the XXXIX Nordic Congress of Ophthalmology. August 4-7, 2010. Reykjavik, Iceland.

Acta ophthalmologica. Supplement·2010
Same journal

Abstracts of the XXXVIII Nordic Congress of Ophthalmology. June 14-17, 2008 Tromsø, Norway.

Acta ophthalmologica. Supplement·2008
Same journal

Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis.

Acta ophthalmologica. Supplement·2008
Same journal

Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.

Acta ophthalmologica. Supplement·2008
See all related articles

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Pathology

Background:

  • Congenital corneal opacity presents a diagnostic challenge, especially when associated with other ocular anomalies.
  • Pre-operative diagnosis of a dermoid was made, necessitating further investigation into the underlying pathology.

Observation:

  • An infant presented with right eye congenital corneal opacity, aniridia, and cataract, alongside left orbit anophthalmia.
  • Clinical course and pathological findings of the keratoplasty specimen were analyzed.

Findings:

  • Histopathology revealed disorganized, vascularized connective tissue with thickened, keratinized epithelium.
  • Absence of Bowman's and Descemet's membranes and endothelium, consistent with a congenital corneal keloid.
  • Co-existence of aniridia and anophthalmia suggests a primary ocular developmental disorder.

Related Experiment Videos

Implications:

  • The findings challenge the notion of a reparative process, pointing towards a primary developmental anomaly.
  • Difficulties in performing penetrating keratoplasty for such congenital corneal keloid lesions are highlighted.
  • Understanding the etiology is crucial for managing similar complex pediatric ocular conditions.