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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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7(th) International Immunoglobulin Conference: Poster presentations.

K Warnatz1, M Ballow, M Stangel

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Summary
This summary is machine-generated.

Immunoglobulin (Ig) therapy is widely used for antibody deficiencies and autoimmune diseases. Current trends show increasing use in transplantation and neuropathies, with ongoing research into optimal dosing and mechanisms of action.

Keywords:
intravenous immunoglobulinneuropathyprimary immunodeficiencysubcutaneous immunoglobulintransplantation

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Area of Science:

  • Immunology
  • Pharmacology
  • Transplantation Medicine

Background:

  • Immunoglobulin (Ig) therapy is a primary treatment for primary antibody deficiency disorders and various autoimmune/inflammatory conditions.
  • Its role in complement activation is driving increased use in solid organ transplantation and immune-mediated neuropathies like CIDP and MMN.

Discussion:

  • Trends in Ig therapy across Europe reveal availability challenges and varied dosing/administration routes, including subcutaneous immunoglobulin (SCIg).
  • Optimization strategies for Ig therapy in neuropathies and primary antibody deficiency (PAD) are being explored, including individualized dosing and biomarkers like antigen-specific T cell responses.

Key Insights:

  • Ig therapy mechanisms may involve immunoregulatory effects mediated by IgG antibodies against glycans.
  • Potential thrombogenic adverse effects of Ig therapy require further investigation, despite being rare.
  • Prophylactic IVIg decreased severe infections in heart transplant recipients with IgG hypogammaglobulinaemia.

Outlook:

  • Further research is needed to clarify the relationship between Ig therapy, adverse reactions, and immunomodulatory effects.
  • Individualized dosing strategies and biomarkers are crucial for optimizing Ig therapy outcomes.
  • The role of Ig therapy in transplantation, particularly in managing infections and allograft survival, warrants continued study.